(DOWNLOAD) "C-Furanosides" by Peter Goekjian, Arnaud Haudrechy, Boudjema Menhour & Claire Coiffier * eBook PDF Kindle ePub Free
eBook details
- Title: C-Furanosides
- Author : Peter Goekjian, Arnaud Haudrechy, Boudjema Menhour & Claire Coiffier
- Release Date : January 30, 2017
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 190427 KB
Description
Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon.
While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems.
Provides a comprehensive review of the growing literature in C-furanosidesEnables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished casesExplores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models
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